Agelity

Keeping mind and body healthy through the years

Overview

D-pinitol helps against age-associated impairment of insulin signaling, lipid metabolism and neurodegeneration-associated mechanisms. These coordinated actions might contribute to prevent insulin resistance, liver steatosis and tau-protein deposition in the brain through unique pharmacological actions.

Discover the unique effects of Agelity

Benefits

D-pinitol, the inositol for a healthy aging

Healthy aging is a global demand. Insulin resistance, chronic liver metabolic dysfunction and neurodegeneration associated to tau-protein deposition are among the main disorders that complicate the natural process of aging. Finding accesible solutions is an unmet clicnical need.

D-Pinitol improves carbohydrate and lipid metabolism, and reduce factors promoting neurodegeneration

D-Pinitol is a natural orally active inositol improving insulin resitance by concerted actions on pancreas and the liver. It reduces fat deposition in the liver, helping to avoid steatohepatitis, and reduces the risk of neurodegeneration (including Alzheimer’s Disease). Overall, its consumption is a preventive strategy for chronic disorders accelerating age-associated dissabilities.

TECHNICAL INFORMATION

Prevention of insulin resistance and neurodegeneration

D-Pinitol reduces the burden of work of the pancreatic islets associated with hyperglicaemia. This action helps to prevent insulin resistance and lipid deposition in the liver. In addition, D-Pinitol reduces tau fosforilation, helping to reduce neurodegeneration associated to tauopathies including alzheimer’s Disease. This effect is achieved though modulation of CDK5, a key enzyme in neurodegeneration and inflammation.

Appearance:

White to off-white-crystalline powder.

Small molecule
Assay (USP):

min 98,0%

Dosage:

Oral

Bioaviability:

High

Loss on drying:

máx. 2%.

Solubility in water:

Soluble.

Melting range:

ca. 179-185 ºC

Taste:

Only slightly sweet, no distinct side-or aftertaste

Stability:

Stable under normal processing and storage conditions.

Disclaimer

Information presented in this leaflet is intended to provide general information on our premium products, their properties and potential applications. It is based on our present state of knowledge and must not be construed as guaranteeing specific properties or approvals of the products described herein or their suitability for any application described. The user is solely responsible for compliance with the existing approvals in the county of use. It is also in the sole responsibility of the user to investigate whether existing patents are infringed by the use of the materials described herein. Adequate quality of our products is guaranteed under our General Conditions of Sales.

All statements in this leaflet have not been evaluated by the US Food and Drug Administration or EFSA. This product is not intended to diagnose, treat, cure, or prevent any disease.

Research(es)

[1] Navarro et al. (2020) conducted a study on Wistar rats to investigate the effects of orally administered D-pinitol from Ceratonia siliqua on pancreas insulin secretion and circulating ghrelin levels.

[2] López-Gambero et al. (2020) discussed the potential biomedical uses of inositols in addressing metabolic dysfunction in aging and neurodegenerative diseases.

[3] López-Gambero et al. (2021) investigated the association between negative energy balance and metabolic dysfunctions in the hypothalamus of a humanized preclinical model of Alzheimer’s disease, the 5XFAD mouse.

[4] Medina-Vera et al. (2021) investigated the activation of the PI3K/Akt signaling pathway in the rat hypothalamus induced by an acute oral administration of D-pinitol.

[5] Medina-Vera et al. (2022) investigated the potential of D-pinitol to promote tau dephosphorylation through a cyclin-dependent kinase 5 regulation mechanism.

[6] Navarro et al. (2022) conducted a pharmacokinetic and endocrine study on fasting healthy human volunteers who were given an oral dose of D-pinitol.

Resources

22/08/2020

22/08/2020

11/05/2022